The federal government shutdown continues with no resolution, devastating nonprofit operations nationwide through frozen grants, delayed payments, and furloughed federal partners. One-third of nonprofits report government funding disruptions since January, with organizations facing unprecedented threats including criminal investigations of major foundations, illegal grant withholding, and politicized oversight. Nonprofits helped organize October 18 No Kings protests. Brown University and MIT rejected Trump administration proposals offering priority funding in exchange for institutional commitments threatening academic freedom. New tax legislation alters charitable giving incentives through universal deductions and corporate contribution floors. Meanwhile, regulatory changes reshape compliance obligations across HHS grants, controlled substances ordering, and employment practices. State attorneys general coordinate resistance to federal overreach while California expands nonprofit funding eligibility.