The nonprofit sector faces unprecedented operational challenges as the federal government shutdown enters its second week, disrupting grant payments, workforce stability, and regulatory oversight. Organizations must navigate immediate cash flow pressures while the administration escalates investigations targeting progressive foundations and advocacy groups. Critical developments include HHS’s revised grants policy effective October 1, Massachusetts’s new pay transparency requirements beginning October 29, and DOL’s aggressive H-1B enforcement initiative. State governments lack capacity to replace federal funding gaps, and philanthropic response remains limited despite sector-wide appeals. November Form 990 deadlines remain in effect despite shutdown complications. Organizations need immediate action on workforce planning, grant compliance, and operational contingencies.