The nonprofit sector confronts unprecedented operational challenges in November 2025 as federal funding disruptions intensify during the second-longest government shutdown in U.S. history. With 36% of organizations operating at deficit, 42 million Americans facing SNAP funding exhaustion, and Hurricane Melissa devastating Caribbean communities, nonprofits must navigate simultaneous crises while federal oversight increases and traditional funding sources contract. Organizations face immediate workforce decisions, emergency cash management requirements, and strategic imperatives to diversify revenue streams. This comprehensive update provides essential intelligence on regulatory developments, compliance requirements, and actionable strategies for nonprofit leaders managing through this volatile period while maintaining mission delivery to communities experiencing escalating needs.